mTOR Signaling in Metabolism and Cancer

Download or read book mTOR Signaling in Metabolism and Cancer written by Shile Huang and published by MDPI. This book was released on 2020-12-03 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this Special Issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting mTOR pathway is a promising strategy to fight against certain human diseases.