Restoring Functional Behaviors After Traumatic Peripheral Nerve Injuries

Download or read book Restoring Functional Behaviors After Traumatic Peripheral Nerve Injuries written by George Davis Bittner and published by Frontiers Media SA. This book was released on 2024-02-20 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peripheral nerve injuries (PNIs) by trauma are the most common neuronal injury in civilian and military populations and significantly burden health care systems. Mammals (including humans) with PNIs experience: (1) immediate loss of sensory and motor functions mediated by the denervated target tissues; (2) rapid (3-7d) Wallerian Degeneration (WD) of severed distal axonal segments; and, (3) slow (~1mm/day) regeneration by naturally occurring axonal outgrowths from surviving, severed proximal stumps that produce poor (if any) functional recovery because of slow axonal regeneration for long distances and lack of axonal guidance. Denervated muscle fibers and sensory organs often atrophy before any re-innervation can occur.