Cybernetic Modeling for Bioreaction Engineering

Download or read book Cybernetic Modeling for Bioreaction Engineering written by Doraiswami Ramkrishna and published by Cambridge University Press. This book was released on 2018-10-18 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uniquely focusing on dynamic modeling, this volume incorporates metabolic regulation as a survival mechanism for cells, by driving metabolism through optimal investment of its resources for control of enzyme synthesis and activity. Consequently, the models have a proven record of describing various uptake patterns of mixed carbon substrates that have become significant in modern applications of biomass for the production of bioenergy. The models accurately describe dynamic behavior of microbes in nutrient environments with mixtures of complementary substrates, such as carbon and nitrogen. Modeling of large metabolic networks (including prospects for extension to genome scale) is enabled by lumped hybrid cybernetic models with an unparalleled capacity to predict dynamic behavior of knockout strains. This is an invaluable, must-have reference for bio-researchers and practicing engineers.