Is adaptive randomization always better than traditional fixed-schedule randomization? Which procedures should be used and under which circumstances? What speci

This book covers domains of modern clinical trial design: classical, group sequential, adaptive, and Bayesian methods applicable to and used in various phases o

Praise for the First Edition “All medical statisticians involved in clinical trials should read this book…” - Controlled Clinical Trials Featuring a uniqu

Although adaptive design methods are flexible and useful in clinical research, little or no regulatory guidelines are available. One of the first books on the t

All the Essentials to Start Using Adaptive Designs in No TimeCompared to traditional clinical trial designs, adaptive designs often lead to increased success ra