Purinergic Signalling and the Nervous System

Purinergic Signalling and the Nervous System
Author :
Publisher : Springer Science & Business Media
Total Pages : 724
Release :
ISBN-10 : 9783642288630
ISBN-13 : 3642288634
Rating : 4/5 (30 Downloads)

Book Synopsis Purinergic Signalling and the Nervous System by : Geoffrey Burnstock

Download or read book Purinergic Signalling and the Nervous System written by Geoffrey Burnstock and published by Springer Science & Business Media. This book was released on 2012-06-05 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.


Purinergic Signalling and the Nervous System Related Books

Purinergic Signalling and the Nervous System
Language: en
Pages: 724
Authors: Geoffrey Burnstock
Categories: Medical
Type: BOOK - Published: 2012-06-05 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so
Purinergic Signaling in Neurodevelopment, Neuroinflammation and Neurodegeneration
Language: en
Pages: 381
Authors: Henning Ulrich
Categories: Medical
Type: BOOK - Published: 2023-07-16 - Publisher: Springer Nature

DOWNLOAD EBOOK

This volume explores the quickly evolving field of Purinergic signaling, and examines how receptors for ATP and other nucleotides, and receptors for adenosine,
Receptors P1 and P2 as Targets for Drug Therapy in Humans
Language: en
Pages: 112
Authors: Robson Faria
Categories: Medical
Type: BOOK - Published: 2020-03-11 - Publisher: BoD – Books on Demand

DOWNLOAD EBOOK

This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate
Purinergic Signaling and Inflammation
Language: en
Pages: 97
Authors: Davide Ferrari
Categories: Medical
Type: BOOK - Published: 2021-07-14 - Publisher: Frontiers Media SA

DOWNLOAD EBOOK

Pharmacology of Purine and Pyrimidine Receptors
Language: en
Pages: 558
Authors:
Categories: Science
Type: BOOK - Published: 2011-07-13 - Publisher: Academic Press

DOWNLOAD EBOOK

This is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors. - Authors are the leading authorities in their fields