Screening-level Hazard Assessment of Human and Environmental Health Endpoints of Halogenated and Organophosphate Flame Retardants

Download or read book Screening-level Hazard Assessment of Human and Environmental Health Endpoints of Halogenated and Organophosphate Flame Retardants written by Seth Rojello Fernández and published by . This book was released on 2019 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organohalogen flame retardants are extensively used in both industrial and consumer products but now are being phased out of circulation by both state governments and the United States Federal government. Organophosphate flame retardants have been chosen as the replacement for the halogenated flame retardants. However, relatively little is known about the potential hazard of these class of chemicals to cause adverse health and environmental effects. To address this, we conducted a health and environmental hazard screening of 90 halogenated and 97 organophosphate flame retardants based on the GreenScreen® or Quick Chemical Assessment Tool (QCAT©) methodologies. Priority consideration was given to human health hazards including carcinogenicity (including mutagenicity and genetic toxicity), reproductive or developmental toxicity, endocrine disruption, and acute mammalian toxicity. Environmental hazards given priority consideration included acute aquatic toxicity, persistence, and bioaccumulation. Using publicly available information, each hazard category was assigned a concern level (very-low, low, moderate, high, or very high) based on pre-defined numerical ranges, such as no-observed adverse effect levels and hazard classification schemes from authoritative sources, when available. Where empirical data were not identified, quantitative structure-activity relationship (QSAR) models were relied upon to predict hazard potential. After assigning concern levels for each priority health effect, each chemical received a score, similar to a report card (A, B, C, or F). The majority of the screened chemicals received an F grade due to empirical data suggesting high hazard, QSAR model predictions, and/or excessive data gaps. Acute Mammalian Toxicity was the most prominent potential health hazard identified based on empirical data. The most prevalent data gap was found in both reproductive toxicity and endocrine disruption endpoints due to the lack of identified empirical data or computer models able to predict this hazard. This study highlights the limited toxicity information available for these widely used chemical classes and indicates that more testing and oversight is critically needed to identify safer alternatives for fire prevention.