Toxicology of Essential and Xenobiotic Metals

Download or read book Toxicology of Essential and Xenobiotic Metals written by João Batista Teixeira Da Rocha and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The toxicology of metals is a global concern. Metals exposure induces toxic manifestations by acute or chronic pathologies. Heavy metals such as arsenic (As), cadmium (Cd), mercury (Hg), thallium (Tl), and lead (Pb), are known for their enormous toxicity. Generally, the symptoms of metal intoxication depend upon the type (chemical species), dose, method, and duration of exposure. In an acute metal exposure, the immediate vital signs include nausea, vomiting, diarrhea, and abdominal pain. Humans' and animals' long-term chronic exposure to heavy metals and metalloids can lead to numerous physical, muscular, neurological, nephrological, and diverse degenerative diseases and dysfunctions, including multiple sclerosis, muscular dystrophy, cardiovascular disorders, Parkinson's, and Alzheimer's diseases. The understanding of the metals' interactions with target proteins is essential to identify their metabolism, distribution, and toxicity. The modulation of the redox biology status by metals is a critical point in its toxicological action. Mercury has been identified as the most toxic heavy metal, and its poisoning is known as acrodynia or pink disease. The development of analytical sensitivity techniques and methodologies to detect very small amounts of some toxic metals (Pb and Hg), at the molecular level, is essential. The data described in this book is intended to be a reference for health professionals and students of toxicology"--