Tyrosine Kinases as Druggable Targets in Cancer

Tyrosine Kinases as Druggable Targets in Cancer
Author :
Publisher : BoD – Books on Demand
Total Pages : 136
Release :
ISBN-10 : 9781789848083
ISBN-13 : 1789848083
Rating : 4/5 (83 Downloads)

Book Synopsis Tyrosine Kinases as Druggable Targets in Cancer by : Huan Ren

Download or read book Tyrosine Kinases as Druggable Targets in Cancer written by Huan Ren and published by BoD – Books on Demand. This book was released on 2019-09-25 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management. In this book, we examine a few aspects of PTKs and cancer, considering efficacy, predictive markers to therapeutic response, limitations, and future directions in TKI treatment. In this rapidly evolving field, overcoming therapeutic resistance is most challenging, and multi-targeting directs the next-generation TKIs and combination therapy as ongoing strategies in cancer treatment.


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