A Metabolomic Modelling Approach for Functional Microbiome Analysis

Download or read book A Metabolomic Modelling Approach for Functional Microbiome Analysis written by Jasmine Chong and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The gut microbiome is a complex biological system that impacts many aspects of human health. While several studies have identified long lists of microbes implicated in disease, why they are associated with differential host phenotypes remains unclear. Metabolomics can complement sequencing-based approaches by providing a snapshot of host-microbial co-metabolism, however, its use in the field of microbiomics is still in its infancy. The objectives of my project are therefore to (i) to become proficient in metabolomics data processing and analysis and translate this knowledge into the development of bioinformatics tools for metabolomics data, (ii) to improve biological insights obtained from untargeted metabolomics data in an open-source and transparent matter, and (iii) to implement a novel bioinformatic framework to integrate untargeted metabolomics data and taxonomic microbial data to model changes in microbial metabolism. Ultimately, this framework will permit researchers to understand metabolic mechanisms of the gut microbiome and aide the design of novel therapeutics"--