An Update on Neurological Disorders Post COVID-19 Infection

Download or read book An Update on Neurological Disorders Post COVID-19 Infection written by Beatrice Paradiso and published by Frontiers Media SA. This book was released on 2023-08-02 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronavirus disease 2019 (COVID-19), produces the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with atypical pneumonia. This infection is a global health challenge producing post-acute sequelae of SARS-CoV-2 infection (PASC), including neuro-PASC in which direct or indirect invasion of the virus into the brain causes immune dysregulation, hormonal disorders, elevated cytokine levels due to immune reaction and chronic inflammation, direct tissue injury, and persistent low-grade infection. The COVID-19 induced-neuroinflammation promotes blood-brain barrier (BBB) disruption, access of antigens and inflammatory factors into the brain, as well as infection or immune-mediated response in the neuromuscular system. It is therefore necessary to explore whether there is a close correlation with the adenosine pathway, the activation of the ACE receptor by the virus, the concentration of IL6 and the neuro-invasive effect of COVID-19. Other points of interest are the analysis of the autonomic dysfunction induced by cytokines; the effect of vaccine mRNA delivery in Central and Peripheral Nervous System, the long-term effects of Covid 19 infection and/or therapeutic approach in different pandemic countries. In this Research Topic we aim to including submissions and research from different countries, which will allow comparisons of loco-regional clinical experiences, diagnostic flow-charts, and different therapeutic approaches.