Cytokine Profile Description in Rheumatoid Arthritis Patients Without Treatment and After Three Months of Treatment

Download or read book Cytokine Profile Description in Rheumatoid Arthritis Patients Without Treatment and After Three Months of Treatment written by Andrés Camilo Diaz Valencia and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid arthritis is a frequent life deteriorating disease that has a 1,49% prevalence in Colombia and is disabling in approximately 40% of the cases. As a chronic disease there is a need to improve diagnosis and treatment response monitoring to increase patient remission rate and reduce the impact in life quality. In this study we aimed to measure the concentration of IL-6, IL-18 and TNFRSF9 as biomarkers of treatment response in 10 treatment-naive patients recruited in a Colombian rheumatology reference center. We explored the association between the levels of these molecules before and after treatment with standard clinical variables (i.e. ESR, DAS28 and life quality measurements). Measurement of proinflammatory molecule levels was performed with dot blot and detection with digitally detected ECL. Cytokine concentrations were reduced after treatment in 9 of the 10 subjects showing a behavior consistent with therapy response. No association was observed between their levels and measured standard...