Investigations of Cellular and Molecular Biophysical Properties by Atomic Force Microscopy Nanorobotics

Download or read book Investigations of Cellular and Molecular Biophysical Properties by Atomic Force Microscopy Nanorobotics written by Mi Li and published by Springer. This book was released on 2017-10-06 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents methodological and application research in detecting cellular and molecular biophysical properties based on atomic force microscopy (AFM) nanorobotics. Series methods for in situ label-free visualizing and quantifying the multiple physical properties of single cells and single molecules were developed, including immobilization strategies for observing fine structures of living cells, measurements of single-cell mechanics, force recognition of molecular interactions, and mapping protein organizations on cell surface. The biomedical applications of these methods in clinical lymphoma treatments were explored in detail, including primary sample preparation, cancer cell recognition, AFM detection and data analysis. Future directions about the biomedical applications of AFM are also given.