Laron Syndrome - From Man to Mouse
Author | : Zvi Laron |
Publisher | : Springer Science & Business Media |
Total Pages | : 514 |
Release | : 2010-11-25 |
ISBN-10 | : 9783642111839 |
ISBN-13 | : 3642111831 |
Rating | : 4/5 (39 Downloads) |
Download or read book Laron Syndrome - From Man to Mouse written by Zvi Laron and published by Springer Science & Business Media. This book was released on 2010-11-25 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.