Miniaturization and Mass Spectrometry

Miniaturization and Mass Spectrometry
Author :
Publisher : Royal Society of Chemistry
Total Pages : 332
Release :
ISBN-10 : 9781847558947
ISBN-13 : 1847558941
Rating : 4/5 (47 Downloads)

Book Synopsis Miniaturization and Mass Spectrometry by : Severine le Gac

Download or read book Miniaturization and Mass Spectrometry written by Severine le Gac and published by Royal Society of Chemistry. This book was released on 2008-12-03 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent explosion in the use of analytical chemistry, particularly in the biological sciences, has led to a need for fast, reliable and highly sensitive tools able to handle small sample sizes. This book illustrates how microfluidics and lab-on-a-chip devices can satisfy the growing need for miniaturized and enhanced analysis. They lend themselves well to mass spectrometric detection as they use samples in the low microlitre range and are handled on a chip. Miniaturization and Mass Spectrometry focuses on one particular technique, mass spectrometry, whose popularity has increased dramatically in the last two decades with the increase in use of biological analysis and the development of two "soft" ionization techniques, ESI and MALDI. These enable the analysis of large but fragile biological molecules such as DNA, proteins and oligosaccharides. The book starts with an introduction to the coupling of microfluidics to mass spectrometry techniques. It then goes on demonstrate the advantages of such a coupling: the MS analysis benefits from improved sample preparation when performed on a chip while MS yields more information on the sample handled on the chip compared to conventional optical detection. A history on the developments in this field, starting from the off-chip coupling to the on-chip ionization, is also provided. Daniel Figeys, a pioneer in the development of microfluidic systems for MS analysis, describes the early beginnings of this hyphenated analysis technique. Solutions to couple microfluidic systems to the two most popular ionization methods, ESI and MALDI, are presented throughout the chapters. Various examples are given of the application of this microfluidics-MS hyphenated analysis technique to proteomics, metabolomics, organic chemistry and forensics. Coverage is not limited to academic research. The development of commercialized systems and their current use for routine biological analysis are also presented. Lastly, a future vision of the integration of the mass spectrometer on the chip is raised, as a last step to yield fully portable systems for on-site analysis.


Miniaturization and Mass Spectrometry Related Books

Miniaturization and Mass Spectrometry
Language: en
Pages: 332
Authors: Severine le Gac
Categories: Science
Type: BOOK - Published: 2008-12-03 - Publisher: Royal Society of Chemistry

DOWNLOAD EBOOK

The recent explosion in the use of analytical chemistry, particularly in the biological sciences, has led to a need for fast, reliable and highly sensitive tool
Miniaturization and Mass Spectrometry
Language: en
Pages: 333
Authors: Séverine Le Gac
Categories: Science
Type: BOOK - Published: 2009 - Publisher: Royal Society of Chemistry

DOWNLOAD EBOOK

Focussing on mass spectrometry, this book illustrates how microfluidics and lab-on-a-chip devices satisfy the need for miniaturized, enhanced chemical analysis.
Ambient Ionization Mass Spectrometry
Language: en
Pages: 528
Authors: Marek Domin
Categories: Science
Type: BOOK - Published: 2014-11-25 - Publisher: Royal Society of Chemistry

DOWNLOAD EBOOK

Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. I
Portable Spectroscopy and Spectrometry, Applications
Language: en
Pages: 608
Authors: Richard A. Crocombe
Categories: Science
Type: BOOK - Published: 2021-04-28 - Publisher: John Wiley & Sons

DOWNLOAD EBOOK

The most comprehensive resource available on the many applications of portable spectrometers, including material not found in any other published work Portable
Quadrupole Mass Spectrometry and Its Applications
Language: en
Pages: 372
Authors: Peter H. Dawson
Categories: Science
Type: BOOK - Published: 2013-10-22 - Publisher: Elsevier

DOWNLOAD EBOOK

Quadrupole Mass Spectrometry and Its Applications provides a comprehensive discussion of quadrupoles and their applications. It proceeds from a general explanat