Molecular Nutrition and Mitochondria

Download or read book Molecular Nutrition and Mitochondria written by Sergej M. Ostojic and published by Academic Press. This book was released on 2022-10-20 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals provides a comprehensive examination of molecular aspects of mitochondrial nutrition and how dietary compounds might impact the treatment of mitochondrial dysfunction. Beginning with an overview of the fundamentals of mitochondria physiology and the methods used to evaluate mitochondrial imbalance in clinical practice, the book goes on to outline nutritional shortfalls in mitochondrial dysfunction and highlights the complex intra-organelle milieu affecting interactions between food compounds and mitochondrial co-factors, metabolites, and signaling molecules. Further sections explore the impact of essential nutrients, such as vitamin E, fatty acids, and complex lipids, on mitochondrial biogenesis, as well as non-essential bioactive compounds originating from food that can be evaluated for their mitochondria-modulating potential, such as mitochondria-targeted small molecule antioxidants, plant-based pigments and organic compounds, nucleotides, non-proteogenic amino acids and derivatives, and mitochondria-specific enzyme mimetics from food. Molecular Nutrition and Mitochondria covers the key impacts of nutrition on mitochondria, and is the ideal reference for researchers, students and clinicians looking to develop an in-depth understanding of how dietary compounds can prevent and treat disorders associated with mitochondrial dysfunction. Describes the fundamentals of mitochondria physiology and considers the methods used to evaluate mitochondrial imbalance in clinical practice Provides broad biochemical and metabolic background on nutritional deficits found in mitochondrial dysfunction Explores the prevention and treatment of various inherited and acquired disorders associated with mitochondrial dysfunction Discusses the link between the dosage for each nutrient (nutritional vs. pharmacological) and the clinical effect Features a dedicated section on whole-diet interventions and mitochondrial function