Pharmacogenomics Implementation: From Concept to Practice

Download or read book Pharmacogenomics Implementation: From Concept to Practice written by Miriam Saiz-Rodríguez and published by Frontiers Media SA. This book was released on 2024-07-10 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pharmacogenomics has experienced an unprecedented and exponential progress in recent years. Several pharmacogenomic biomarkers have been identified that have clinical practical value for the effective management of multiple pathologic disorders. Pharmacogenomic biomarkers sometimes help estimate the therapeutic window for specific patient populations and thereby help maximize patient safety. Translation of preclinical research discoveries in this expanding field into meaningful clinical diagnostic and therapeutic advances, especially in the context of precision medicine, is a focal point of contemporary research efforts. A better understanding of the genetic and epigenetic influencers of clinical responses to therapeutic agents is of paramount importance. On one hand, much remains to be deciphered and discovered through breakthrough research. On the other hand, existing information needs to be better disseminated to become part of the clinical decision process. In addition, there is a need for complementary health economics research to support the implementation of these validated biomarkers in routine clinical practice. Ultimately, these efforts are likely to improve treatment outcomes even in difficult-to-treat disease and provide the foundation for more effective personalized treatment strategies for a broad-spectrum of illnesses.