Regulation of SNF2h Chromatin Remodeling Activity

Download or read book Regulation of SNF2h Chromatin Remodeling Activity written by He, Xi and published by . This book was released on 2007 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: ATP-dependent chromatin remodeling is performed by ATPase-containing complexes of the SNF2 super family. There are three major sub-families of remodeling complexes: SWI/SNF, CHD, and ISWI. The diversity of ISWI-based complexes is conserved in organisms. For example, in human the hACF complex consists of hACF1 and human ISWI SNF2h; the CHRAC consists of hACF1, SNF2h, and the p15/p17 dimer; the WICH complex consists of WSTF and SNF2h, and the RSF complex consists of SNF2h and Rsf1. ISWI-based complexes have divergent in vitro as well as in vivo activities. It has been hypothesized that the binding partners regulate ISWI activity differently, therefore resulting in varying in vivo functions of ISWI-based complexes.