Statistical Monitoring of Clinical Trials

Statistical Monitoring of Clinical Trials
Author :
Publisher : Springer Science & Business Media
Total Pages : 284
Release :
ISBN-10 : 0387277811
ISBN-13 : 9780387277813
Rating : 4/5 (11 Downloads)

Book Synopsis Statistical Monitoring of Clinical Trials by : Lemuel A. Moyé

Download or read book Statistical Monitoring of Clinical Trials written by Lemuel A. Moyé and published by Springer Science & Business Media. This book was released on 2006 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Monitoring of Clinical Trials: Fundamentals for Investigators introduces the investigator and statistician to monitoring procedures in clinical research. Clearly presenting the necessary background with limited use of mathematics, this book increases the knowledge, experience, and intuition of investigations in the use of these important procedures now required by the many clinical research efforts. The author provides motivated clinical investigators the background, correct use, and interpretation of these monitoring procedures at an elementary statistical level. He defines terms commonly used such as group sequential procedures and stochastic curtailment in non-mathematical language and discusses the commonly used procedures of Pocock, O’Brien–Fleming, and Lan–DeMets. He discusses the notions of conditional power, monitoring for safety and futility, and monitoring multiple endpoints in the study. The use of monitoring clinical trials is introduced in the context of the evolution of clinical research and one chapter is devoted to the more recent Bayesian procedures. Dr. Lemuel A. Moyé, M.D., Ph.D. is a physician and a biostatistician at the University of Texas School of Public Health. He is a diplomat of the National Board of Medical Examiners and is currently Professor of Biostatistics at the University of Texas School of Public Health in Houston where he holds a full time faculty position. Dr. Moyé has carried out cardiovascular research for twenty years and continues to be involved in the design, execution and analysis of clinical trials, both reporting to and serving on many Data Monitoring Committees. He has served in several clinical trials sponsored by both the U.S. government and private industry. In addition, Dr. Moyé has served as statistician/epidemiologist for six years on both the Cardiovascular and Renal Drug Advisory Committee to the Food and Drug Administration and the Pharmacy Sciences Advisory Committee to the FDA. He has published over 120 manuscripts in peer-reviewed literature that discuss the design, execution and analysis of clinical research. He authored Statistical Reasoning in Medicine: The Intuitive P-value Primer (Springer, 2000) and Multiple Analysis in Clinical Trials: Fundamentals for Investigators (Springer, 2003).


Statistical Monitoring of Clinical Trials Related Books

Introduction to Statistical Methods for Clinical Trials
Language: en
Pages: 465
Authors: Thomas D. Cook
Categories: Mathematics
Type: BOOK - Published: 2007-11-19 - Publisher: CRC Press

DOWNLOAD EBOOK

Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, fr
Statistical Monitoring of Clinical Trials
Language: en
Pages: 263
Authors: Michael A. Proschan
Categories: Medical
Type: BOOK - Published: 2006-12-31 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

The approach taken in this book is, to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Lim
Statistical Thinking in Clinical Trials
Language: en
Pages: 276
Authors: Michael A. Proschan
Categories: Mathematics
Type: BOOK - Published: 2021-11-24 - Publisher: CRC Press

DOWNLOAD EBOOK

Statistical Thinking in Clinical Trials combines a relatively small number of key statistical principles and several instructive clinical trials to gently guide
Data Monitoring Committees in Clinical Trials
Language: en
Pages: 208
Authors: Susan S. Ellenberg
Categories: Mathematics
Type: BOOK - Published: 2003-01-17 - Publisher: John Wiley & Sons

DOWNLOAD EBOOK

There has been substantial growth in the use of data monitoring committees in recent years, by both government agencies and the pharmaceutical industry. This gr
Data Monitoring in Clinical Trials
Language: en
Pages: 389
Authors: David L. DeMets
Categories: Medical
Type: BOOK - Published: 2006-06-22 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

From the authors of "Fundamentals of Clinical Trials" which has sold over 15,000 copies world wide since its publication in 1998. No competition yet as the text