Understanding the Pathogenesis of Tuberculosis (T.B.) for the Discovery of New Therapeutic Targets at Molecular Level: Recent Perspectives for an Old Disease.

Download or read book Understanding the Pathogenesis of Tuberculosis (T.B.) for the Discovery of New Therapeutic Targets at Molecular Level: Recent Perspectives for an Old Disease. written by Dr.Hakim Saboowala and published by Dr.Hakim Saboowala. This book was released on 2020-07-06 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the Pathogenesis of Tuberculosis (T.B.) for the Discovery of New Therapeutic Targets at Molecular Level: Recent Perspectives for an Old Disease. The history of tuberculosis (TB) mixtures with the history of humanity since TB is one of the oldest infectious diseases affecting mankind. Bone TB was identified in 4000 years old skeletons, from Europe and Middle East, as the cause of death. Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. An attempt has been made in this Booklet to focus on the innate immunity of this disease reviewing: 1. Well-established and consensual mechanisms like: o Mycobacterium tuberculosis interference with phagosome maturation, Less consensual mechanism like: o Nitric oxide production, and 3. New mechanisms, such as: o Mycobacteria translocation to the cytosol, o Autophagy, and Apoptosis/Necrosis proposed mainly during the last decade. …Dr. H. K. Saboowala. M.B.(Bom). M. R. S. H. (London).